C-CBL phosphorylation status influences colorectal cancer cell survival in a Wnt-dependent manner
Hyperactive Wnt signaling is the seminal event in colorectal cancer (CRC) pathogenesis, where β-catenin serves as a key Wnt mediator enhancing CRC cell proliferation and survival. c-Cbl is a unique E3 ligase, which degrades both mutant and active (tumorigenic) β-catenin. c-Cbl phosphorylation at ty...
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| Language: | en_US |
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2016
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| Online Access: | https://hdl.handle.net/2144/16145 |