Vascular smooth muscle Sirtuin-1 protects against aortic dissection during angiotensin II–induced hypertension
BACKGROUND: Sirtuin-1 (SirT1), a nicotinamide adenine dinucleotide+ –dependent deacetylase, is a key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, the role of endogenous SirT1 in the vasculature has not been fully elucidated. Our goal was to evaluate th...
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| Language: | en_US |
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2016
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| Online Access: | https://hdl.handle.net/2144/16774 |