The role of TLE4 as a tumor suppressor in acute myeloid leukemia and regulator of hematopoietic and bone development
The presence of AML1-ETO (RUNX1-CBF2T1), a fusion oncoprotein resulting from a t(8;21) chromosomal translocation, is a necessary but insufficient event in the development of a subset of acute myeloid leukemias (AML). Although AML1-ETO is able to block differentiation and immortalize hematopoietic st...
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| Language: | en_US |
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2017
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| Online Access: | https://hdl.handle.net/2144/20324 |