Novel mechanisms of eIF2B action and regulation by eIF2alpha phoshorylation
Eukaryotic translation initiation factor 2 (eIF2) is a heterotrimeric G-protein that plays a critical role in protein synthesis regulation. eIF2-GTP binds Met-tRNAi to form the eIF2-GTP:Met-tRNAi ternary complex (TC), that is recruited to the 40S ribosomal subunit. Following GTP hydrolysis, eIF2-GDP...
| Main Author: | |
|---|---|
| Language: | en_US |
| Published: |
2017
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/2144/20818 |