Examination of the role of envelope directed antibodies on co-receptor usage in HIV-1B infection
HIV-1 primarily utilizes the CCR5 receptor as a co-receptor, but over time, viruses can evolve to use the CXCR4 protein. Changes in the viral envelope V3 loop mediate this switch. The emergence of CXCR4-utilizing viruses has been presumed to occur as a consequence of decreased humoral immunity. We s...
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| Language: | en_US |
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2018
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| Online Access: | https://hdl.handle.net/2144/29958 |