Feminization of male mouse liver by continuous growth hormone infusion or loss of EZH1/2: activation of sex-biased transcriptional networks and dynamic changes in chromatin states
The sex-dependent pituitary growth hormone (GH) secretory profiles, pulsatile in males and persistent in females, regulate sex-biased expression of hundreds of genes in mammalian liver, contributing to sex differences in hepatic metabolism and disease. The sex-biased GH actions in the liver are medi...
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| Language: | en_US |
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2018
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| Online Access: | https://hdl.handle.net/2144/29989 |