Biophysical characterization of affinity maturation in the human response to anthrax vaccine
Affinity maturation increases the affinity of B-cell derived antibodies to their cognate antigens. In this study, we characterized the kinetic, structural, dynamic and thermodynamic evolution of antibodies during affinity maturation. Through single B-cell cell sorting, paired heavy and light chain s...
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| Language: | en_US |
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2018
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| Online Access: | https://hdl.handle.net/2144/32958 |