Design, synthesis and testing of calpain inhibitors for the treatment of cataract
This thesis reports the development of potent and selective inhibitors of m-calpain for the treatment of cataract. SJA6017 has been proven to prevent lens opacity in rat and has been our lead compound. A series of Val-Leu peptidyl aldehyde inhibitors (33a-e, 33g, 33i and 35) have been designed, s...
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| Language: | en |
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University of Canterbury. Chemistry
2008
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| Online Access: | http://hdl.handle.net/10092/1405 |