Disrupting the quaternary structure of DHDPS as a new approach to antibiotic design.
This thesis examined the enzyme dihydrodipicolinate synthase (DHDPS, E.C. 4.2.1.52) from the pathogen Mycobacterium tuberculosis. DHDPS is a validated antibiotic target for which no potent inhibitor based on substrates, intermediates or product has been found. The importance of the homotetrameric qu...
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Language: | en |
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University of Canterbury. Biological Sciences
2010
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Online Access: | http://hdl.handle.net/10092/4469 |