Disrupting the quaternary structure of DHDPS as a new approach to antibiotic design.

Disrupting the quaternary structure of DHDPS as a new approach to antibiotic design.

This thesis examined the enzyme dihydrodipicolinate synthase (DHDPS, E.C. 4.2.1.52) from the pathogen Mycobacterium tuberculosis. DHDPS is a validated antibiotic target for which no potent inhibitor based on substrates, intermediates or product has been found. The importance of the homotetrameric qu...

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Bibliographic Details
Main Author: Evans, Genevieve Laura
Language:en
Published: University of Canterbury. Biological Sciences 2010
Subjects:
dihydrodipicolinate synthase
DHDPS
lysine biosynthesis
diaminopimelate pathway
amino acid biosynthesis
dapA
Rv2753c
Mycobacterium tuberculosis
dimer
dimer-dimer interface
quaternary structure
Online Access:http://hdl.handle.net/10092/4469

Internet

http://hdl.handle.net/10092/4469

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