Controlling the substrate specificity of α-isopropylmalate synthase and related enzymes
The enzyme α-isopropylmalate synthase (IPMS) catalyses the reaction between acetyl coenzyme A (AcCoA) and α-ketoisovalerate (KIV) to produce free coenzyme A and α isopropylmalate (IPM). This reaction is a key control point in the biosynthesis of a leucine, a pathway absent in animals but present in...
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| Language: | en |
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University of Canterbury. Department of Chemistry
2013
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| Online Access: | http://hdl.handle.net/10092/8727 |