Mdm2 and MdmX as Regulators of Gene Expression
Mdm2 and MdmX are RING domain proteins that bind to and inhibit p53 trans-activation functions. Moreover, Mdm2 interacts with p53 and targets it for degradation. However, Mdm2 and MdmX function beyond a simple inhibition of p53, and increasing evidence suggests functions in regulation of target gene...
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| Language: | English |
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2012
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| Online Access: | https://doi.org/10.7916/D82N5094 |