Gates and Latches: the mechanochemistry of ATP binding in kinesin 1 and Eg5
This thesis explores the role of mechanochemistry in two biological systems. The first system investigated involves cargo transport along microtubule filaments by Kinesin 1. A gating mechanism is needed to coordinate ATP binding to the two catalytic domains within Kinesin 1 in order to prevent simul...
Main Author: | Behnke-Parks, William M. |
---|---|
Language: | English |
Published: |
2011
|
Subjects: | |
Online Access: | https://doi.org/10.7916/D83B66HW |
Similar Items
-
Mechanochemistry of Human DNA G-quadruplexes Revealed by Single-molecule Optical Tweezers
by: Yu, Zhongbo
Published: (2013) -
Measuring microtubule binding kinetics of membrane-bound kinesin motors using supported lipid bilayers
by: Rui Jiang, et al.
Published: (2021-09-01) - Modulators of Myosin Activity and Actomyosin Interaction: Potential for 2'-Deoxy-Atp (dATP) as a Positive Inotrope in Cardiac Muscle
-
Regulation of Eg5 and TPX2 during mammalian mitosis
by: Titus, Janel
Published: (2013) -
Allosteric Coupling, Nucleotide Binding and ATP Hydrolysis by Hsp70 Chaperones on a Structural Basis
by: Wang, Wei
Published: (2018)