Two-stage Continual Reassessment Method and Patient Heterogeneity for Dose-finding Studies
The continual reassessment method (CRM) is a widely used model-based design in Phase I dose-finding studies. This dissertation examines two extensions of CRM: one is a two-stage method and the other is a method that accounts for patient heterogeneity. Originally proposed in the Bayesian framework, C...
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| Language: | English |
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2014
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| Online Access: | https://doi.org/10.7916/D8FQ9TN5 |