Computational design, synthesis, and biological evaluation of small molecule anti-cancer therapeutics
It’s estimated that as many as 80% of the existing potential cancer targets are considered to be ‘undruggable’. The vast majority of these targets engage in protein-protein interactions (PPIs). Within this class are the RAS GTPases (HRAS, KRAS (4A and 4B), NRAS), which are the most frequently mutate...
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| Language: | English |
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2015
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| Online Access: | https://doi.org/10.7916/D8P84B9P |