Functional Characterization of the Mammalian TRPV4 Channel: Yeast Screen Reveals Gain-of-Function Mutations

Transient receptor potential (TRP) channels are a class of six-transmembrane (6-TM) cation-permeable channels that mediate flux of calcium and sodium into cells, leading to depolarization as well as activation of calcium-mediated second-messenger signaling pathways. The TRP channel family is large a...

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Bibliographic Details
Main Author: Doyle, Christina
Language:English
Published: 2012
Subjects:
Online Access:https://doi.org/10.7916/D8RB7BM5