Interaction study of ribosome-inactivating proteins (RIPs) and ribosomes and increasing the specificity of ricin A chain toward HIV-1 protease by protein engineering.

Interaction study of ribosome-inactivating proteins (RIPs) and ribosomes and increasing the specificity of ricin A chain toward HIV-1 protease by protein engineering.

核糖體抑活蛋白 (RIPs) 屬於糖苷酶的一種，能從23S或28S核糖體核糖核酸中的sarcin-ricin環(sarcin-ricin loop, SRL)移除一個特定的腺嘌呤，引致核糖體失效。由於核糖體蛋白協助RIP到達SRL，因此它們對RIP的核糖體特認性是極大的重要。雖然各RIPs的份子結構及催化活動非常相似，它們的核糖體特認性和效力存著很大的迥異。此外，現時還未能找出只有少數RIPs能同時抑制原核和真核生物的核糖體的原因。我們試圖從玉米核糖體抑活蛋白 (Maize RIP) 和真核生物的核糖體以及志賀毒素 (Shiga toxin) 和原核生物的核糖體的相互作用的研究中去解釋以上的現...

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Bibliographic Details
Other Authors: Wong, Yuen-Ting
Format: Others
Language:English
Chinese
Published: 2012
Subjects:
Hydrolases
Protease inhibitors
Antiviral agents
Ribosome Inactivating Proteins
HIV Protease Inhibitors
Anti-HIV Agents
Online Access:http://library.cuhk.edu.hk/record=b5549526
http://repository.lib.cuhk.edu.hk/en/item/cuhk-328030

Internet

http://library.cuhk.edu.hk/record=b5549526
http://repository.lib.cuhk.edu.hk/en/item/cuhk-328030

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