Selenocystine induces mitochondrial-mediated apoptosis in breast carcinoma MCF-7 cells and melanoma A-375 cells with involvement of p53 phosphorylation and reactive oxygen species.

Selenocystine induces mitochondrial-mediated apoptosis in breast carcinoma MCF-7 cells and melanoma A-375 cells with involvement of p53 phosphorylation and reactive oxygen species.

Additionally, we showed that SeC induced S-phase arrest in MCF-7 cells associated with a marked decrease in the protein expression of cyclin A, D1 and D3 and cyclin-dependent kinases (CDK) 4 and 6, with concomitant induction of p21waf1/Cip1, p27Kip1 and p53. Expose of MCF-7 cells to SeC resulted in...

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Bibliographic Details
Other Authors: Chen, Tianfeng.
Format: Others
Language:English
Chinese
Published: 2008
Subjects:
Apoptosis
Breast > Cancer > Chemotherapy
Melanoma > Chemotherapy
Organoselenium compounds > Therapeutic use
Phosphorylation
Selenium > Therapeutic use
Breast Neoplasms > drug therapy
Melanoma > drug therapy
Organoselenium Compounds > therapeutic use
Selenium > therapeutic use
Online Access:http://library.cuhk.edu.hk/record=b6074646
http://repository.lib.cuhk.edu.hk/en/item/cuhk-344279

Internet

http://library.cuhk.edu.hk/record=b6074646
http://repository.lib.cuhk.edu.hk/en/item/cuhk-344279

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