High-throughput discovery and detection of viral mutations in hepatitis B virus quasi-species for patients undergoing antiviral therapy.
HBV DNA replicates through a genomic RNA intermediate. The HBV reverse transcriptase lacks proof-reading activity, resulting in a much higher mutation rate for the HBV genome compared with other DNA viruses. HBV DNA thus is often present in quasi-species in an individual. One or more species may be...
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| Format: | Others |
| Language: | English Chinese |
| Published: |
2009
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| Online Access: | http://library.cuhk.edu.hk/record=b6074765 http://repository.lib.cuhk.edu.hk/en/item/cuhk-344398 |