Profiling of substrate-specificity and rational design of peptidomimetic inhibitors for 3C-like proteases of coronaviruses.
3C-like protease (3CLpro) of severe acute respiratory syndrome-coronavirus (SARS-CoV) is required for autoprocessing of the polyproteins 1a and 1ab, and is a potential target for treating coronaviral infection. To obtain a thorough understanding of its substrate preference, we created a substrate li...
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| Format: | Others |
| Language: | English Chinese |
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2010
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| Online Access: | http://library.cuhk.edu.hk/record=b6075034 http://repository.lib.cuhk.edu.hk/en/item/cuhk-344667 |