CD4 Aptamer-SiRNA Chimeras (CD4-AsiCs) Knockdown Gene Expression in CD4+ Cells and Inhibit HIV Transmission
The continued spread of HIV underscores the need to interrupt transmission. One attractive strategy is a topical microbicide. Sexual transmission of herpes simplex virus type 2 (HSV-2) in mice can be inhibited by intravaginal small inhibitory RNA (siRNA) application. To overcome the challenges of...
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| Language: | en_US |
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Harvard University
2013
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| Online Access: | http://dissertations.umi.com/gsas.harvard:10272 http://nrs.harvard.edu/urn-3:HUL.InstRepos:10288421 |