Mitochondrial Priming Determines Chemotherapeutic Response in Acute Myeloid Leukemia
Gain- and loss-of-function studies of the BCL-2 family of proteins have shown that they can impact chemotherapeutic sensitivity. However, cells contain myriad anti-apoptotic and pro-apoptotic BCL-2 family members making it difficult to predict cell fate decisions based on the initial conditions of...
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| Language: | en_US |
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Harvard University
2013
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| Online Access: | http://dissertations.umi.com/gsas.harvard:10384 http://nrs.harvard.edu/urn-3:HUL.InstRepos:10288428 |