Mitochondrial Priming Determines Chemotherapeutic Response in Acute Myeloid Leukemia
Gain- and loss-of-function studies of the BCL-2 family of proteins have shown that they can impact chemotherapeutic sensitivity. However, cells contain myriad anti-apoptotic and pro-apoptotic BCL-2 family members making it difficult to predict cell fate decisions based on the initial conditions of...
Main Author: | |
---|---|
Other Authors: | |
Language: | en_US |
Published: |
Harvard University
2013
|
Subjects: | |
Online Access: | http://dissertations.umi.com/gsas.harvard:10384 http://nrs.harvard.edu/urn-3:HUL.InstRepos:10288428 |