Molecular Insight into Function of the Evolutionarily Conserved Brd4 Extraterminal Domain (ET) and Mechanism of Brd4 Functions in Human Diseases
Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression and virus-host pathogenesis. Papillomaviruses (PV) E2 protein associates with Brd4 and this interaction is important for transcriptional regulation of the viral oncogenes by E2 as well as viral genome maintenance in...
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| Language: | en_US |
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Harvard University
2013
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| Online Access: | http://dissertations.umi.com/gsas.harvard:10204 http://nrs.harvard.edu/urn-3:HUL.InstRepos:10288517 |