Molecular Insight into Function of the Evolutionarily Conserved Brd4 Extraterminal Domain (ET) and Mechanism of Brd4 Functions in Human Diseases
Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression and virus-host pathogenesis. Papillomaviruses (PV) E2 protein associates with Brd4 and this interaction is important for transcriptional regulation of the viral oncogenes by E2 as well as viral genome maintenance in...
Main Author: | Rahman, Shaila |
---|---|
Other Authors: | Howley, Peter M. |
Language: | en_US |
Published: |
Harvard University
2013
|
Subjects: | |
Online Access: | http://dissertations.umi.com/gsas.harvard:10204 http://nrs.harvard.edu/urn-3:HUL.InstRepos:10288517 |
Similar Items
-
Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function
by: Adam P. Cribbs, et al.
Published: (2021-02-01) -
Current Understanding of the Role of the Brd4 Protein in the Papillomavirus Lifecycle
by: Moon Kyoo Jang, et al.
Published: (2013-05-01) -
BRD4: An emerging prospective therapeutic target in glioma
by: Hua Yang, et al.
Published: (2021-06-01) -
Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression
by: Jin Dai, et al.
Published: (2019-02-01) -
Discovery of novel coumarin derivatives as potent and orally bioavailable BRD4 inhibitors based on scaffold hopping
by: Zhimin Zhang, et al.
Published: (2019-01-01)