Clonal Analysis of Mucosal SIV-Specific CD8+ T Cell Responses
CD8+ T cells responses are critical in the immune defense against human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection. A major challenge for vaccine development is that HIV/SIV can rapidly mutate to escape containment by the CD8+ T cell response. Therefore, optimal v...
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| Language: | en_US |
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Harvard University
2013
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| Online Access: | http://dissertations.umi.com/gsas.harvard:10035 http://nrs.harvard.edu/urn-3:HUL.InstRepos:10345145 |