Multiplicative Expansion of the Pool of Fully Synthetic Tetracycline Antibiotics
This thesis describes the development of chemical pathways for the preparation of more than 80 novel fully synthetic tetracyclines with structural variability at positions C5 and C5a. Progress toward the synthesis of 5-hetero-tetracyclines, another new class of tetracycline antibiotics, is also desc...
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| Language: | en_US |
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Harvard University
2013
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| Online Access: | http://dissertations.umi.com/gsas.harvard:10504 http://nrs.harvard.edu/urn-3:HUL.InstRepos:10364587 |