Defining the Landscape of the PARKIN- and PINK1-Dependent Ubiquitin-Modified Proteome in Response to Mitochondrial Dysfunction

Defining the Landscape of the PARKIN- and PINK1-Dependent Ubiquitin-Modified Proteome in Response to Mitochondrial Dysfunction

Parkinson's disease (PD) is a progressive neurological disorder resulting from loss of dopaminergic neurons of the substantia nigra, in part due to mitochondrial dysfunction. The E3 ubiquitin ligase, PARKIN, and mitochondrial kinase, PINK1, found mutated in familial early onset recessive forms...

Full description

Bibliographic Details
Main Author: Sarraf, Shireen Akhavan
Other Authors: Harper, J. Wade
Language:en_US
Published: Harvard University 2013
Subjects:
Cellular biology
Molecular biology
diGly
Parkin
Parkinson's
Pink1
Proteomics
Ubiquitin
Online Access:http://dissertations.umi.com/gsas.harvard:10939
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11110427

Internet

http://dissertations.umi.com/gsas.harvard:10939
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11110427

Similar Items