Defining the Landscape of the PARKIN- and PINK1-Dependent Ubiquitin-Modified Proteome in Response to Mitochondrial Dysfunction
Parkinson's disease (PD) is a progressive neurological disorder resulting from loss of dopaminergic neurons of the substantia nigra, in part due to mitochondrial dysfunction. The E3 ubiquitin ligase, PARKIN, and mitochondrial kinase, PINK1, found mutated in familial early onset recessive forms...
Main Author: | Sarraf, Shireen Akhavan |
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Other Authors: | Harper, J. Wade |
Language: | en_US |
Published: |
Harvard University
2013
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Subjects: | |
Online Access: | http://dissertations.umi.com/gsas.harvard:10939 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11110427 |
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