Hypothesis Testing in GWAS and Statistical Issues with Compensation in Clinical Trials
We first show theoretically and in simulation how power varies as a function of SNP correlation structure with currently-implemented gene-based testing methods. We propose alternative testing methods whose power does not vary with the correlation structure. We then propose hypothesis tests for det...
| Main Author: | |
|---|---|
| Other Authors: | |
| Language: | en_US |
| Published: |
Harvard University
2013
|
| Subjects: | |
| Online Access: | http://dissertations.umi.com/gsas.harvard:10909 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11124831 |