New Mechanisms of Activation by Histone Demethylases in Gene Regulation
The epigenetic mechanisms that connect hormone signaling to chromatin remain largely unknown. Here we show that LSD1/KDM1A is a critical glucocorticoid receptor (GR) coactivator and report a previously unexplored mechanism where LSD1 activates gene transcription through H3K4me2 demethylation. We dem...
| Main Author: | |
|---|---|
| Other Authors: | |
| Language: | en_US |
| Published: |
Harvard University
2013
|
| Subjects: | |
| Online Access: | http://dissertations.umi.com/gsas.harvard:11135 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11169798 |