Inhibition of Cdc42 during mitotic exit is required for cytokinesis in Saccharomyces cerevisiae
Rho GTPases are highly conserved regulators of cell polarity and the actin cytoskeleton. The role of the Rho GTPase Cdc42 and its regulation during cell division is not well understood. Using biochemical and imaging approaches in budding yeast, I demonstrate that Cdc42 activation peaks during the G1...
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| Language: | en_US |
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Harvard University
2014
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| Online Access: | http://dissertations.umi.com/gsas.harvard:11257 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11744465 |