Chemical Probes and the Exploration of Bromodomains in Cancer Biology
The post-translational modification of histones and their interaction with transcription factors is essential to gene regulation. Furthermore, these targets would greatly benefit from probe molecules to fully elucidate their biological actions and to potentially lead to therapeutics. However, these...
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| Language: | en_US |
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Harvard University
2014
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| Online Access: | http://dissertations.umi.com/gsas.harvard:11468 http://nrs.harvard.edu/urn-3:HUL.InstRepos:12269851 |