Social Behavior and Gene Expression Disturbances in Mouse Models of Angelman Syndrome and Idic15 Autism

Social Behavior and Gene Expression Disturbances in Mouse Models of Angelman Syndrome and Idic15 Autism

Reciprocal changes in UBE3A gene dosage cause two neurodevelopmental disorders. Maternally inherited deletions of UBE3A cause Angelman syndrome, characterized by intellectual disability, motor defects, seizures, and a pathognomonic increased social motivation. Whereas maternally inherited triplicati...

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Bibliographic Details
Main Author: Stoppel, David Christopher
Other Authors: Anderson, Matthew Peter
Language:en_US
Published: Harvard University 2014
Subjects:
Neurosciences
Behavioral sciences
Angelman Syndrome
Autism
Idic15
Social Behavior
Ube3a
Online Access:http://dissertations.umi.com/gsas.harvard:11314
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274549

Internet

http://dissertations.umi.com/gsas.harvard:11314
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274549

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