Social Behavior and Gene Expression Disturbances in Mouse Models of Angelman Syndrome and Idic15 Autism
Reciprocal changes in UBE3A gene dosage cause two neurodevelopmental disorders. Maternally inherited deletions of UBE3A cause Angelman syndrome, characterized by intellectual disability, motor defects, seizures, and a pathognomonic increased social motivation. Whereas maternally inherited triplicati...
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| Language: | en_US |
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Harvard University
2014
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| Online Access: | http://dissertations.umi.com/gsas.harvard:11314 http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274549 |