CRISPR-Cas: Development and applications for mammalian genome editing

The ability to introduce targeted modifications into genomes and engineer model organisms holds enormous promise for biomedical and technological applications, and has driven the development of tools such as zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs). T...

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Bibliographic Details
Main Author: Ran, Fei Ann
Other Authors: Zhang, Feng
Language:en_US
Published: Harvard University 2014
Subjects:
Online Access:http://dissertations.umi.com/gsas.harvard:11610
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274628