Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes
Poly(ADP-ribose)polymerase-1 and -2 (PARP1/2) are nuclear proteins involved in DNA repair. Tumors with defects in homologous recombination, including BRCA1- and BRCA2-deficient cancers, have been shown to be sensitive to PARP inhibition. The Weissleder group has synthesized fluorescent and radi...
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| Format: | Others |
| Language: | en |
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Harvard University
2014
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| Online Access: | http://etds.lib.harvard.edu/hms/admin/view/58 http://nrs.harvard.edu/urn-3:HUL.InstRepos:12407616 |