Viral and Host Determinants of Primate Lentivirus Restriction by Old World Primate TRIM5alpha Proteins
The host restriction factor TRIM5α mediates a post-entry, pre-integration block to retroviral infection that depends upon recognition of the viral capsid by the TRIM5α PRYSPRY domain. The two predominant alleles of rhesus macaque TRIM5α (rhTRIM5αQ and rhTRIM5αTFP) restrict HIV 1, but cannot restrict...
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| Language: | en_US |
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Harvard University
2014
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| Online Access: | http://dissertations.umi.com/gsas.harvard.inactive:11770 http://nrs.harvard.edu/urn-3:HUL.InstRepos:13065027 |