Development of the CRISPR nuclease Cas9 for high precision mammalian genome engineering
Recent advances in genome engineering technologies based on the CRISPR-associated RNA-guided endonuclease Cas9 are enabling the systematic interrogation of genome function. Analogous to the search function in modern word processors, Cas9 can be guided to specific locations within complex genomes by...
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| Language: | en_US |
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Harvard University
2014
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| Online Access: | http://dissertations.umi.com/gsas.harvard.inactive:11838 http://nrs.harvard.edu/urn-3:HUL.InstRepos:13068392 |