Niemann-Pick C1 Is Essential for Ebola Virus Infection and a Target of Small Molecule Inhibitors

Niemann-Pick C1 Is Essential for Ebola Virus Infection and a Target of Small Molecule Inhibitors

Ebolavirus (EboV) is a highly pathogenic enveloped virus that causes outbreaks of zoonotic infection in Africa. The clinical symptoms are manifestations of the massive production of pro-inflammatory cytokines in response to infection and in many outbreaks, case fatality rate exceeds 75%. The unpredi...

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Bibliographic Details
Main Author: Bruchez, Anna
Other Authors: Cunningham, James Morgan
Language:en_US
Published: Harvard University 2012
Subjects:
entry factor
inhibitor
Niemann-Pick C1
NPC1
small molecules
virology
ebolavirus
Online Access:http://dissertations.umi.com/gsas.harvard:10654
http://nrs.harvard.edu/urn-3:HUL.InstRepos:9861675

Internet

http://dissertations.umi.com/gsas.harvard:10654
http://nrs.harvard.edu/urn-3:HUL.InstRepos:9861675

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