Silver-Mediated Trifluoromethoxylation of Aryl Nucleophiles and Synthesis of 3-Deoxy-3-Fluoromorphine
Fluorine incorporation has become increasingly important in pharmaceutical applications. Upon fluorination and incorporation of fluorinated moieties such as trifluoromethoxy groups, many small molecules become more bioavailable and metabolically stable and additionally can better cross the blood-bra...
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| Language: | en_US |
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Harvard University
2012
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| Online Access: | http://dissertations.umi.com/gsas.harvard:10547 http://nrs.harvard.edu/urn-3:HUL.InstRepos:9904007 |