Investigations into the asymmetric reduction of ketones
A six-step synthesis of salbutamol from methyl salicylate with an overall yield of 17% has been completed, although the yield was not optimised. In the process, Zn(BH4)2 was found to selectively reduce a ketone carbonyl group in the presence of an ester unit. In contrast, borane was found to reduce...
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| Format: | Others |
| Language: | English |
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University of Port Elizabeth
2003
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| Online Access: | http://hdl.handle.net/10948/323 |