The influence of a methylated-β-Cyclodextrin on the solubility and photostability of midazolam in aqueous solution

Midazolam, used clinically as an anticonvulsant, anxiolytic, muscle relaxant and sedative is a photolabile imidazo-benzodiazepine which is marketed under the trade names Dormicum® and Hypnovel® as tablets and injectables. Because of an aqueous solubility of < 0.1 mg/ml above pH 4, the preparation...

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Bibliographic Details
Main Author: Lebete, Mosimotsana Leah
Format: Others
Language:English
Published: Rhodes University 2001
Subjects:
Online Access:http://hdl.handle.net/10962/d1005923