Studies towards the synthesis of novel, coumarin-based HIV-1 protease inhibitors

Studies towards the synthesis of novel, coumarin-based HIV-1 protease inhibitors

A series of the Baylis-Hillman adducts have been obtained by reacting protected O-benzylated and unprotected substituted salicylaldehydes with methyl acrylate or tertbutyl acrylate, respectively, using DABCO as catalyst. Treatment of the Baylis-Hillman adducts with HCl in a mixture of acetic acid an...

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Bibliographic Details
Main Author: Rashamuse, Thompho Jason
Format: Others
Language:English
Published: Rhodes University 2008
Subjects:
Coumarins
Protease Inhibitors
HIV infections > Treatment
HIV (Viruses)
AIDS (Disease) > Treatment
Heterocyclic compounds > Derivatives
Online Access:http://hdl.handle.net/10962/d1005024

Internet

http://hdl.handle.net/10962/d1005024

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