Hyperglycemia-induced activation of the hexosamine biosynthetic pathway causes myocardial cell death

Hyperglycemia-induced activation of the hexosamine biosynthetic pathway causes myocardial cell death

Thesis (PhD (Physiological Sciences))--University of Stellenbosch, 2009. === ENGLISH ABSTRACT: OBJECTIVE – Oxidative stress increases flux through the hexosamine biosynthetic pathway (HBP) resulting in greater O-GlcNAcylation of target proteins. Since increased oxidative stress and HBP flux are as...

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Bibliographic Details
Main Author: Rajamani, Uthra
Other Authors: Essop, M. Faadiel
Language:en
Published: Stellenbosch : University of Stellenbosch 2009
Subjects:
Hexosamine biosynthetic pathway
Dissertations > Physiological sciences
Theses > Physiological sciences
Hyperglycemia
Heart > Physiology
Hexosamines
Coronary heart disease
Cell death
Online Access:http://hdl.handle.net/10019.1/1142

Internet

http://hdl.handle.net/10019.1/1142

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