Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity

The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination.

Bibliographic Details
Main Author: Mbele, Prisca
Other Authors: Chapman, Ros
Format: Doctoral Thesis
Language:English
Published: University of Cape Town 2015
Subjects:
Online Access:http://hdl.handle.net/11427/10930
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-109302020-07-22T05:07:37Z Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity Mbele, Prisca Chapman, Ros Williamson, Anna-Lise Medical Virology The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination. 2015-01-02T08:55:22Z 2015-01-02T08:55:22Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/10930 eng application/pdf University of Cape Town Faculty of Health Sciences Division of Virology
collection NDLTD
language English
format Doctoral Thesis
sources NDLTD
topic Medical Virology
spellingShingle Medical Virology
Mbele, Prisca
Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity
description The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination.
author2 Chapman, Ros
author_facet Chapman, Ros
Mbele, Prisca
author Mbele, Prisca
author_sort Mbele, Prisca
title Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity
title_short Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity
title_full Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity
title_fullStr Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity
title_full_unstemmed Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity
title_sort evaluation of a reverse tetracycline inducible system in recombinant bcg to improve stability and immunogenicity
publisher University of Cape Town
publishDate 2015
url http://hdl.handle.net/11427/10930
work_keys_str_mv AT mbeleprisca evaluationofareversetetracyclineinduciblesysteminrecombinantbcgtoimprovestabilityandimmunogenicity
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