Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity
The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination.
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University of Cape Town
2015
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Online Access: | http://hdl.handle.net/11427/10930 |
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ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-109302020-07-22T05:07:37Z Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity Mbele, Prisca Chapman, Ros Williamson, Anna-Lise Medical Virology The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination. 2015-01-02T08:55:22Z 2015-01-02T08:55:22Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/10930 eng application/pdf University of Cape Town Faculty of Health Sciences Division of Virology |
collection |
NDLTD |
language |
English |
format |
Doctoral Thesis |
sources |
NDLTD |
topic |
Medical Virology |
spellingShingle |
Medical Virology Mbele, Prisca Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity |
description |
The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination. |
author2 |
Chapman, Ros |
author_facet |
Chapman, Ros Mbele, Prisca |
author |
Mbele, Prisca |
author_sort |
Mbele, Prisca |
title |
Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity |
title_short |
Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity |
title_full |
Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity |
title_fullStr |
Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity |
title_full_unstemmed |
Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity |
title_sort |
evaluation of a reverse tetracycline inducible system in recombinant bcg to improve stability and immunogenicity |
publisher |
University of Cape Town |
publishDate |
2015 |
url |
http://hdl.handle.net/11427/10930 |
work_keys_str_mv |
AT mbeleprisca evaluationofareversetetracyclineinduciblesysteminrecombinantbcgtoimprovestabilityandimmunogenicity |
_version_ |
1719330022901153792 |