The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer
Includes abstract. === Includes bibliographical references (leaves 102-131). === T-box factors play crucial roles in embryogenesis and mutations in T-box factor genes have been implicated in multiple human disorders. In addition, an increasing body of evidence implicates the T-box family in cell cyc...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Doctoral Thesis |
| Language: | English |
| Published: |
University of Cape Town
2015
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/11427/11890 |
| Summary: | Includes abstract. === Includes bibliographical references (leaves 102-131). === T-box factors play crucial roles in embryogenesis and mutations in T-box factor genes have been implicated in multiple human disorders. In addition, an increasing body of evidence implicates the T-box family in cell cycle regulation and in cancer...The aim of this study was therefore to address this question by establishing TBX2 over-expression and knockdown cell culture models. The results show that TBX2 does indeed contribute directly to the oncogenic process and further reveals a novel mechanism by which it contributes to tumourigenesis. |
|---|