The determination and validation of population pharmacokinetic parameters of phenytoin in adult epileptic patients in the Western Cape using nonlinear mixed-effects modelling
The pharmacokinetics of phenytoin is complicated by the nonlinearity of the dose-concentration relationship which is a consequence of capacity-limited metabolism. Individualized therapy with phenytoin is therefore optimally required. As no data are available on the population pharmacokinetics of phe...
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| Format: | Doctoral Thesis |
| Language: | English |
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University of Cape Town
2017
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| Online Access: | http://hdl.handle.net/11427/26609 |