Synthesis and investigation of benzimidazole and carbazole ß-haematin inhibiting scaffolds with antimalarial activity
Chloroquine was one of the main malarial treatments until the late 1960s when resistance began to emerge. This antimalarial targets haemozoin formation which causes a cytotoxic accumulation of free haem in the malaria parasite leading to parasite death. This is still one of the most promising pathwa...
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| Format: | Others |
| Language: | English |
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University of Cape Town
2018
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| Online Access: | http://hdl.handle.net/11427/28432 |