Iron overload and Mycobacterium tuberculosis infection: iron chelation modulates pathogen replication and monocyte-macrophage defence.
Background: Elevated levels of iron impair immune defence mechanisms specifically cell mediated immunity and macrophage function, favors infection with Mycobacterium tuberculosis (M.tb), its replication, progression to clinical disease and death form tuberculosis (TB). Chelation of iron in individua...
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2008
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| Online Access: | http://hdl.handle.net/10210/340 |