Quantitative imaging of tyrosine kinase-drug interactions in cells.
Kinases play a crucial role in regulating cellular signaling cascades, making them therapeutic targets for several human diseases. In human cancers, mis-regulation and mutations of kinases such as EGFR (epidermal growth factor receptor) have been found to drive malignant transformation. Due to the c...
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| Language: | en_ZA |
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2013
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| Online Access: | http://hdl.handle.net/10413/8575 |